MPOX IRIS Syndrome - high mortality of unvaccinated immuncompromised humans and HIV patients

in Pandemic Forum29 days ago (edited)


Monkeypox_Virus_(52103767506).jpg
Credits: NHIAD byCC BY 2.0 Licence

During the MPOX outbreak at 2022 the Case fatality rate (CFR) was below 0.1%.

Now with the Clade 1b the case fatality rate of MPOX has significant increased to 3-4% among all MPOX cases at Africa. ECDC has now warned within a bulletin to healthcare workers about the high risk of death by MPOX infection at immunecompromised and HIV infected patients - especially those which are starting an antiviral therapy against HIV and developing an IRIS Syndrom when the immunsystem of these patients starts to restore its immuncompetence after starting its antiviral therapy.

A 15% mortality rate was described among individuals with advanced HIV-related disease characterised by CD4 cell counts below 200 cells per mm3 [43]. An immune reconstitution inflammatory syndrome (IRIS) to mpox was suspected in 21 (25%) out of 85 people who were initiated or re-initiated on antiretroviral therapy (ART), of whom 57% died. ECDC

More than 57% mortality at the Clade 2 infected population was oberserved. From my point of view this Case fatality rate will rise at the patient subpopulation in case of Clade 1b infection up to nearly 90% if the immunsystem restarts during an MPOX Infection.

While Clade 2 normally has less than 20 skin lessions, the new clase 1b is able to develope more than 100 skin lessions which are able to occur at the palm of the hands and feets - very painful and combined with pruritus in the deeper parts of the skin. Scrathing effects can lead to bacterial superinfections resulting in more severe disease course.

Beyond severe infections of the eye - called MPXROD - even pneuomonia, encephalitis and genital ulcer - especially at immuncompromised inviduals were observed at the clase 1b MPOX cases.

High risk if severe disease also excist at childs below age of 10 and pregnant woman.

Sexual transmission of MPOX virus has been described up to 12 weeks after infection.

Animal to human is further a concern about transmission of the highly contagious MPOX Virus.

Further information is available at ECDC - Link

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Das bullöse Pemphigoid ist eine wirklich schwere Erkrankung - hatte bei meinen Recherchen zur C-19 Genspritze und dermatologische Manifestationen davon gelesen.

Herr RA Ulbrich vertritt einen Patienten in genau so einem Fall. Dieser hatte seine Leidensgeschichte letztes Jahr öffentlich gemacht.

Ich glaub es stand kurz darauf auch in der Bild.

In Deutschland darf man das nicht mal denken. In den USA wird offen darüber diskutiert, ob das nicht im Grunde eine Nebenwirkung dieser Injektion sein könnte. Dieses Bild kursiert gerade auf Facebook und Co.

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Das MPOX Virus hat nichts mit dem Vektor des Antigens aus dem Gentherapeutikum von Astra Zeneca zu tun.

Das hier der medizinische Laie einen Zusammenhang herzustellen versucht entbehrt im Falle von MPOX jeglicher Grundlage.

Die sorgfältige Differenzierung zwischen den Viren lässt keinen Zusammenhang zu MPOX zu.

Aus einem Apfel wird keine Birne und ebensowenig umgekehrt.

The vaccine is really dangerous and needs to be incorporated

Every vaccine has a risk. The benefits should outweight the risk of a disease.

I would prefer 4th Generation Vaccine, but never toxic mRNA injections.